Johns Hopkins University
Bloomberg School of Public Health


Constantine E. Frangakis : Publications


Frangakis, CE, Rubin, DB, An, MW, and MacKenzie (2007). Principal stratification designs to estimate input data missing due to death. Biometrics (with Discussion) 63, 641662. [ paper ; discussions by Xie and Murphy ; TenHave, Robins et al ; rejoinder ]


Segal JB, Griswold M, Achy-Brou A, Herbert R, Bass EB, Dy SM, Millman AE, Wu AW, Frangakis CE. (2007). Using propensity scores subclassification to estimate effects of longitudinal treatments: an example using a new diabetes medication. Med Care. 2007 Oct;45(10 Supl 2):S149-57.


Martin, BK, Frangakis, CE, Rosenberg, PB, et al. (2006). Design of Depression in Alzheimer's Disease Study-2. American Journal of Geriatric Psychiatry 14, 920-930.


Li, F and Frangakis, CE (2006). Polydesigns in causal inference. Biometrics, 62, 343--351 [Full text -PDF].


Frangakis, CE (2007). The importance of an intervention-based causal theory for falsifiable-based practice. Discussion of article by A Forcina on ``Causal effects in the presence of non-compliance: a latent variables approach''. Metron 64, 1- ?.


Huang IC, Willke, RJ, Atkinson, MJ, Lenderking, WR, Frangakis, C and Wu, AW (2007). US and UK versions of the EQ-5D preference weights: Does choice of preference weights make a difference? Quality of Life Research 16, 1065--1072.


Dassopoulos, T, Frangakis, CE, Cruz-Correa, M, Talor, MV, Burek, CL, Nouvet, F, Bayless, TM, Brant, SR. (2006). Antibodies to Saccharomyces cerevisiae in Crohn's disease: Higher titers are associated with a greater frequency of mutant NOD2/CARD15 alleles and with a higher probability of complicated disease. Inflammatory Bowel Diseases, 13 143151.


Georgiades, CS, Liapi, E, Frangakis, CE, Park, J, Kim, HW, Hong, K, and Ggeschwind, JFH (2006). Prognostic accuracy of 12 liver staging systems in patients with unresectable hepatocellular carcinoma treated with transarterial chemoembolization. J Vasc Interv Radiol, 17, 1619--1624 (with Discussion in 18 455-456)


Farmakakis T, Dessypris N, Alexe DM, Frangakis C, Petoussis G, Malliori M, Petridou TE. (2007). Magnitude and object-specific hazards of aspiration and ingestion injuries among children in Greece. Int J Pediatr Otorhinolaryngol. 71(2):317-24


Vlahos, NF, Lipari, C, Bankowski, B, Lai, TH, King, J, Shi, IM, Fragakis, K, and Zhao, Y. (2006). The effect of luteal phase support on endometrial L-Selectin ligand expression following ovarian stimulation with recFSH and Ganirelix Acetate. J Clin Endocrinol Metab, 91, 40434049.


Li, F and Frangakis, CE (2005). Designs for partially controlled studies: messages from a review. Statistical Methods in Medical Research 14, 417-431.


Frangakis, CE, Brookmeyer, RS, Varadhan, R, Mahboobeh, S,  Vlahov, D, and Strathdee, SA. (2004). Methodology for evaluating a partially controlled longitudinal treatment using principal stratification, with application to a Needle Exchange Program. Journal of the American Statistical Association Research, 99, 239-249 [Full text - PDF Software


Doan, BQ, Frangakis, CE, Shugart, YY, and Bailey-Wilson, JE. (2005). Application of the propensity score in a covariate-based linkage analysis of the collaborative study on the genetics of alcoholism. BMC Genetics 6, S33.


Go, V, Frangakis, CE, Van Nam, L, Bergenstrom, A, Sripaipan, T, Zenilman, JM, Celentano, DC, Minh Quan, V. (2006). High HIV sexual risk behaviors and STD prevalence among IDUs in northern Vietnam: implications for a generalized HIV epidemic. Journal of Acquired Immune Deficiency Syndromes 42, 108--115.


Doan, BQ, Sorant, AJM, Frangakis, CE, Bailey-Wilson, JE, Shugart, YY. (2006) Covariate-based linkage analysis: Application of a propensity score as the single covariate consistently improves power to detect linkage. European Journal of Human Genetics 14, 1018--1026.


Huang, IC, Frangakis, CE, and Wu, AW. (2006). The relationship of excess body weight and health-related quality of life (HRQOL): evidence from a population study in Taiwan. International Journal of Obesity 30, 1250--1259.


Huang, IC, Wu, AW, and Frangakis, CE. (2006). Do the SF-36 and WHOQOL-BREF measure the same constructs ? Evidence from the Taiwan population. Quality of Life Research 15, 15--24.


Papadopoulos, FC, Frangakis, CE, Skalkidou, A, Petridou, E, Stevens, RG, Trichopoulos, D. (2005). Exploring lag and duration effect of sunshine in triggering suicide. Journal of Affective Disorders, 88 287--297.


Mock V, Frangakis, CE, et al. (2005). Exercise manages fatigue during breast cancer treatment: A randomized controlled trial. Psycho-oncology, 14, 464-477.


Huang , IC, Dominici , F, Frangakis, CE, Diette, G, Damberg, CL, and Wu, AW (2005). Is risk-adjustor selection more important than statistical approach for provider profiling? Asthma as an example. Medical Decision Making, 25, 20-34.


Huang , IC, Frangakis, CE, Dominici, F, Diette, G, and Wu, AW (2005). Application of a propensity score approach for risk adjustment in profiling multiple physician groups on asthma care. Health Services Research, 40, 253278. [ Full text - PDF]  Software


Huang IC, Diette GB, Dominici F, Frangakis CE, Wu AW. (2005). Variations of physician group profiling indicators for asthma care. American Journal of Managed Care, 11, 38-44.


Li, F, Frangakis, CE, Varadhan, R (2003). Polydesigns in causal inference. Proceedings of the American Statistical Association, Section of Statistics in Epidemiology. [ Full text - PDF]


Varadhan, R and Frangakis, CE (2004). Revealing and addressing length bias and heterogeneous effects in frequency case-crossover studies. American Journal of Epidemiology, 159, 596-602.


Frangakis, CE, and Varadhan, R (2004). Systematizing the evaluation of partially controlled studies using principal stratification: from theory to practice. Forthcoming in Statistica Sinica.


Petridou E, Dessypris N, Frangakis, CE, Belechri M, Mavrou A, Trichopoulos D. (2004). Estimating the population burden of injuries: a comparison of household surveys and Emergency Department surveillance. Forthcoming in Epidemiology.


Papadopoulos CF, Petridou E, Frangakis CE, Farmakakis T, Moller H, Rider G (2004). Switching to Euro: still hard to swallow ? Archives of Diseases in Childhood, (with editorial). 89, 382-383.


Barnard, J, Frangakis, CE, Hill, JL, Rubin, DB.  (2003).  A principal stratification approach to broken randomized experiments: a case study of School Choice vouchers in New York City. Forthcoming in the Journal of the American Statistical Association. (with discussion) [ Full text - PDF]


Lyketsos, CG, DelCampo, L, Steinberg, M, Miles, Q, Steele, RN,  Munro, C, Baker AS, Sheppard, JME, Frangakis, CE, Brandt J, and Rabins, PV. (2003). Treating depression in Alzheimer's disease: Efficacy and safety of sertraline, and the benefits of depression reduction. Forthcoming in the Archives of General Psychiatry.


Frangakis, CE, and Rubin, DB (2002)  Principal stratification  in causal inference.  Biometrics, 58, 21-29. [Full text - PDF][software: README, Code]


Frangakis, CE, Rubin, DB, and Zhou, XH. (2002). Clustered encouragement design with individual noncompliance: Bayesian inference and application to Advance Directive Forms. Biostatistics   3, 147-164 (with discussion by DR Cox, A Berrington, E Goetghebeur, and S Vansteelandt).


Frangakis, CE, and Varadhan,  R (2002).  On Confidence Intervals for Seasonal Risk of Suicides, with Null Values on the Boundary Epidemiology,  forthcoming [ Full text - PDF]. [softtware: click here]


Petridou, E ,Papadopoulos, FC, Frangakis, CESkalkidou, A, and Trichopoulos, D. (2002). A role of sunshine in the triggering of suicide. Epidemiology,  13, 106-109,  (with discussion). [ Full text - PDF]   (discussion and rejoinder). [softtware: click here]


Frangakis, CE, and Baker, SG (2001).  Compliance sub-sampling designs for comparative research:  estimation and optimal planning. Biometrics, 57, 899-907 [Full text-PDF]


Frangakis, CE, and Rubin, DB (2001).  Addressing the idiosyncrasy in estimating survival curves using double-sampling in the presence of self-selected right censoring.  Biometrics ( with discussion)  57, 333-353, [ Full text - PDF] [software:  README, routds.r, routds.dll]


Frangakis, CE, and Rubin, DB (2000).  The defining role of ``principal stratification"  in causal inference: adjusting for post-treatment variables.  Dept. of Statistics Research Report FR2000, Harvard University. In Proceedings of the Epidemiology Section, American Statistical Association (invited paper,   with discussion).


Barnard, J, Frangakis, CE, Hill, J, Rubin, DB.  (2000). School Choice in NY City: A Bayesian Analysis of an Imperfect Randomized Experiment. Forthcoming in Case Studies in Bayesian Statistics   (with discussion) V . 5, Gatsonis et al. (eds.) New York: Springer-Verlag.


Frangakis, CE, and Rubin, DB (1999). On double-sampling survival data under selective right censoring. American Statistical Association, Proceedings of the Biometrics Section, 180-185.


Frangakis, CE, and Rubin, DB (1999). Addressing complications of intention-to-treat analysis in the presence of all-or-none treatment-noncompliance and subsequent missing outcomes. Biometrika, 8, 365-379. [Full text -PDF]


Rubin, DB, and Frangakis, CE (1999). Comment on ``Estimation of the causal effect of a time-varying exposure on the marginal mean of a repeated binary outcome'' by JM Robins, S Greenland, and FC Hu. Journal of the American Statistical Association, 94, 702-704.


Frangakis, CE (1999). Coexistent complications with noncompliance with study-protocols, and implications for statistical analysis. Ph. D. thesis, Department of Statistics, Harvard University.


Frangakis, CE, Rubin, DB, and Zhou, XH (1998). Analyzing the clustered encouragement design: the central role of modeling. In: American Statistical Association, Proceedings of the Biometrics Section,  71-79.


Frangakis, CE, and Rubin, DB (1998). Why Intention-to-treat tests are generally anticonservative in the presence of both treatment-noncompliance and outcome-nonresponse: revealing and handling this phenomenon. Award paper presented at the 1998 meeting, International Biometric Society (ENAR).


Frangakis, CE, and Rubin, DB (1997). A new approach to the idiosyncratic problem of drug-noncompliance with subsequent loss to follow-up. In: American Statistical Associatio, Proceedings of the Biopharmaceutical Section, 206-211.


Petridou, E, Zavitsanos, X, Dessypris, N, Frangakis,  CE, Mandyla, M, Doxiadis, S, and Trichopoulos, D (1997). Adolescents in high-risk trajectory: clustering of risky behavior and the origins of socioeconomic health differentials. Preventive Medicine 26, 215-219.


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